Our Lab
Principal Investigator
Dr. Hansen He
Senior Scientist, Princess Margaret Cancer Centre, University Health Network
Professor, Department of Medical Biophysics, University of Toronto
Joey and Toby Tanenbaum Brazilian Ball Chair in Prostate Cancer Research, University of Toronto
Dr. He is an experimental and computational biologist at Princess Margaret Cancer Centre. His research program focuses on understanding epigenetic mechanisms underlying cancer development, progression and therapy response, with the aim of identifying epigenetic biomarkers and therapeutic targets to improve treatment outcomes of cancer patients.
Dr. He obtained his PhD in molecular biology and bioinformatics at the Institute of Biophysics, Chinese Academy of Sciences in 2008. He then received postdoctoral training under the joint supervision of computational biologist Dr. Shirley Liu and cancer biologist Dr. Myles Brown at the Dana-Farber Cancer Institute and Harvard University. Dr. He was recruited as a scientist at the Princess Margaret Cancer Centre and assistant professor at the Department of Medical Biophysics, University of Toronto in 2013. He was promoted to senior scientist and associate professor in 2018.
Dr. He is recognized internationally for three discoveries that include pioneering the use of chromatin dynamics to predict transcription factor binding, elucidating the roles of noncoding RNAs in cancer biology and illuminating epigenetic vulnerabilities in cancer cells. Dr. He has authored over 70 publications at high profile journals including Cell (2018, 2019), Nature Genetics (2016, 2020) and Nature Cell Biology (2020). The translational research in Dr. He’s laboratory has resulted in one phase II clinical trial and two patents. Dr. He has received many distinctions and recognitions, including a number of new investigator awards from national funding agencies, as well as being named a rising star in prostate cancer research.
Staff
Amelia Navarrete
Administrative Assistant
Dr. Peiran Su
Research Associate
Peiran received his Honours of Bachelor of Science degree at University of Toronto in Biochemistry. Peiran obtained his PhD in the Department of Medical Biophysics, co-supervised by Dr. Ming Tsao. His research is focused on extending the CRISPR screens into SCLC PDX models.
Dr. Zuyao Ni
Research Associate
Zuyao obtained his PhD in Molecular Biology under the supervision of a cancer biologist Dr. Rod Bremner at the Department of Laboratory Medicine and Pathobiology, University of Toronto. He completed his postdoctoral training supervised by transcription biologist Dr. Jack Greenblatt at the Terrence Donnelly Centre for Cellular & Biomolecular Research, and then work as a Research Associate there. Zuyao is currently a research associate at Dr. Hansen He’s group. Zuyao focuses his researches on the molecular mechanisms of transcription regulation and published his work in prestigious journals including Cancer Res (2000), PNAS (2005), Nat Immunol (2008), Nat Struct Mol Biol (2014), Nat Commun (2022), and Nucleic Acids Res (2024). His hobbies include soccer and jogging.
David Cho
Research Assistant
David obtained his HBSc in Cell and Molecular Biology from the University of Toronto. A lab member since October 2024, he is currently investigating the efficacy and safety of lipid nanoparticle-packaged siRNA against ARHGEF2 and METTL3 as a novel therapeutic for colorectal cancer in mouse models.
Postdoctoral Fellows
Dr. Yujuan Wang
Postdoctoral Fellow
Yujuan obtained her PhD from Beijing Normal University. She is currently joining the project of prostate cancer m6A profiling to carry out some validation experiments. Next, she is going to carry out a series of CRISPR screens in cancer cell lines, including but not limited to targeting RNA m6A modifications.
Dr. Xin Xu
Postdoctoral Fellow
Xin completed his first postdoc program at the Institute of Microbiology, Chinese Academy of Sciences. After that, he joined He lab in October 2016. Currently, he is working on identifying functional circRNA in prostate cancer, and aim to provide new improved biomarkers and therapy targets that will lead to better diagnosis and treatment of prostate cancer.
Dr. Xinpei Ci
Postdoctoral Fellow
Xinpei obtained her PhD degree in Genetics at Nankai University, China, and received a two-year joint training at Emory University, USA. Her PhD work studied the role of a prostate cancer suppressor gene by using genetically engineered mouse models. She completed her first postdoc training under the supervision of Dr.Yuzhuo Wang at the Vancouver Prostate Centre, UBC, where she utilized patient-derived xenograft models to identify and study driver genes in prostate cancer hormonal therapy resistance. Xinpei joined Dr. Hansen He’s lab in December 2020 and is currently working on epigenetic mechanisms involved in neuroendocrine prostate cancer.
Dr. Tianyi Chen
Postdoctoral Fellow
Tianyi attended Purdue University for college where she majored in Math and Biology. After graduation, she worked as a Research Associate at Indiana University Bloomington for about two years before attending graduate school at Duke University in 2016. For her PhD, she worked on liver regeneration project in which she applied single-cell omics analysis and molecular genetics to understand how mammalian liver orchestrates its effective tissue recovery in response to acute injury. Tianyi joined He lab in September 2022. Outside of the lab, she enjoys reading, hiking, running, and playing with her cat.
Graduate Students
Peter Her
PhD Candidate
Peter obtained his bachelor’s degree from McGill University with a major in Pharmacology. He is currently a PhD Candidate in the Department of Medical Biophysics, co-supervised by Dr. Benjamin Haibe-Kains. He is interested in characterizing the molecular mechanism and clinical utilization of RNA circularization, and looking at circular RNAs involved in immune regulation and tumour immunity.
Magnus Lam
MSc Student
Magnus obtained his Honours Bachelor of Science from the University of Toronto Scarborough in the Molecular Biology and Biotechnology Co-op program. He spent his Co-op term at the Princess Margaret Cancer Biobank as a Technician. He is currently a MSc student in the Department of Medical Biophysics. His research interests are identifying epigenetic-based therapeutic targets in prostate cancer and the potential of using circulating bacterial DNA methylome as a cancer biomarker.
Vivian Chu
PhD Student
Vivian obtained her Honours Bachelor of Science at the University of Waterloo in Molecular Genetics and Bioinformatics. She is currently a PhD Student in the Department of Medical Biophysics, co-supervised by Dr. Bo Wang. She is interested in applying deep learning algorithms to improve RNA therapeutic development and multi-omic integration to decipher cancer etiology.
Alison Chan
MSc Student
Alison obtained her Honours Bachelor of Science at the University of Toronto with a specialist in Pharmacology and Toxicology. She is currently a MSc student in the Department of Medical Biophysics, co-supervised by Dr. Benjamin Lok. She is interested in studying the role of circular RNAs in small-cell lung cancer development, and investigating their clinical potential as therapeutic targets and diagnostic biomarkers.
Lin Yang
PhD Student
Lin obtained his master’s degree in Bioinformatics from George Washington University in the U.S. He is currently a PhD Student in the Department of Medical Biophysics. He is interested in methodology development based on high-throughput sequencing data specific for single-cell level. Lin is also co-supervised by Dr. Schwartz to develop new algorithms to integrate multiple modularities to infer cell lineage.
Yakup Kohen
PhD Student
